gBritain

 

COST Action Members form United Kingdom

 

Santiago Vernia

Dr Santiago Vernia

RESEARCH TOPIC

The rising prevalence of metabolic pathologies such as obesity, type 2 diabetes (T2D) or non-alcoholic fatty liver disease (NAFLD) constitutes a major health problem. We use both computational and experimental approaches to identify and characterize new metabolic regulators relevant for human metabolic pathologies to uncover novel targets for the design of improved diagnostic and therapeutic strategies. Our goal is to characterize the molecular mechanisms driving obesity-associated liver disease at different stages such as insulin resistance, NAFLD, nonalcoholic steatohepatitis, fibrosis or hepatocellular carcinoma.

 

Affiliation

Metabolism and Gene Regulation Group
Santiago Vernia Lab
MRC London Institute of Medical Sciences

Du Cane Road
London, United Kingdom

ORCID:

WWW: 

 

ACTION MEMBER

MEMBER OF WG2 & WG1

KEYWORDS: Diabetes, Obesity, NAFLD, Stress, HCC

MODEL: cell culture, mice

TISSUE: Adipose tissue, Brain, Liver

DISORDERS: Cancer Inflammatory and immunological disorders Metabolic diseases Diabetes

KAnthony

Dr Karen Anthony

RESEARCH TOPIC

I have several active research interests that stem from expertise in neurodegeneration, neuromuscular disorders and RNA-based gene therapy. Two seemingly unrelated areas of research are Duchenne muscular dystrophy (DMD) and cancer.
Although DMD is primarily a muscle disease, the loss of dystrophin in the brain is associated with a DMD neuropsychiatric syndrome'. We are investigating the neuronal RNA processing of the DMD gene and the function(s) of the most predominant dystrophin variant in the brain, Dp71. Our ultimate aim is to inform the development of brain-targeting treatments for DMD.
Dystrophin has been identified as a tumour suppressor and its expression may be an independent prognostic marker in several cancers. We are investigating a role for the DMD gene in, primarily, neurological cancers.
We are developing RNA-based therapeutic strategies to target DMD gene variants in the brain to support both of these avenues of research. Collaborations welcome.

 

 POSTER PRESENTED AT INAUGURAL MEETING IN BILBAO

Affiliation

Faculty of Health and Society
University of Northampton

University Drive, Northampton, NN1 5PH
Northampton, United Kingdom

ORCID: 0000-0002-3638-2405

WWW:

 

ACTION MEMBER

MEMBER OF WG1, INTERESTED IN WG2 TASKS

KEYWORDS: Dp71, dystrophin, Duchenne, low-grade glioma

MODEL: cell culture, humans

TISSUE: Brain, Muscle, Tumor tissue

DISORDERS: Cancer, Muscular dystrophies/atrophies, Duchene Muscular Dystrophy, Neurological and
neurodegenerative diseases, Dementias, Neuromuscular disorders

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woman ikoneDr Suzan HAMMOND
Affiliation: University of Oxford, Oxford, United Kingdom
ORCID: 0000-0002-5640-7569
Webpage: https://www.dpag.ox.ac.uk/team/suzan-hammond

COST function: MC Member
COST Working Groups: 

 

 

Research interests:
keywords: antisense oligonucleotides, spinal muscular atrophy, Duchenne muscular dystrophy, cell penetrating peptides, neuromuscular disorders
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Dr Linda POPPLEWELL
Affiliation: Royal Holloway University of London
ORCID:
Webpage:

COST function: MC Member, ITC Conference Grant Coordinator
COST Working Groups:

 

Research interests:
keywords: antisense oligonucleótides, eteplirsen, Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, neuromuscular disorders, fibrosis, AAV, gene editing
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Prof Antonios KANARAS
Affiliation: University of Southampton, Highfield campus, Physics and Astronomy, United Kingdom, Southampton
ORCID:
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COST function: Substitute MC Member
COST Working Groups: 

 

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man ikoneProf Dominic WELLS
Affiliation: Royal Veterinary College, Royal College Street, United Kingdom, London
ORCID:
Webpage:

COST function: Substitute MC Member
COST Working Groups: 

 

 

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