DARTER organises various events (Training Schools, Short Term Scientific Missions, Meetings) which primary goal is to create the scientific network and to empower and retain young researchers. The networking tools supported by COST facilitate sharing the expertise, gaining new knowledge and experience and conducting international multiple laboratory research.
COST uses the following networking tools: Working Gropu Meetings, MC & Core Group Meetings, workshops and conferences, training schools, webinars, Short Term Scientific Missions (STMS), ITC Conference Grants (to increase visibility of young researchers from ITC countries and enable their attendance to high profile S&T conference), and data dissemination through various media (research papers, social media, webinars etc.)
Our challenge is to use networking and capacity building in the field of nucleic acid therapy delivery to allow RNA-targeting nucleic acid drugs to reach their full potential and become a mainstream therapeutic option. We aim to assess state of the art and identify gaps in the knowledge to prioritise and align research efforts, which will be achieved by involving academics and industry working in ASO delivery in a kick-off meeting and drafting a whitepaper on the gaps of knowledge.
Planned workshops will allow us to reach consensus on the SOPs, after which we will draft scientific papers. Developed SOPs for the use of models and procedures to assess delivery of ASOs will improve comparison and reproducibility between groups. We plan to choose the best performing models and methods to evaluate the safety and toxicity of ASOs to allow prioritisation of chemical modifications and delivery compounds into preclinical and clinical studies. We will publish the results in at least two white papers. We will share unpublished results, particularly negative results, to avoid duplication of efforts and improve focus on effective compounds (dissemination).
We will organise a special session on negative results during each workshop and conference of the Action. Furthermore, negative results will be published in a focus issue of a scientific journal (dissemination).
We will train researchers in relevant procedures, particularly ECIs and members from ITC countries, through training schools (3-4) and STSMs (+30). We will also apply for a Marie Curie Initial Training Network in year 2-3 of the Action. We will provide fellowships to ECIs from ITCs to attend conferences.
We give particular importance to the dissemination of results to all stakeholders. We will generate lay documents for each essential scientific publication, and crucial information will be published on the DARTER Action website and distributed via newsletters and social media. Moreover, we will train ECIs in presenting their work to patients.