WG2 Model systems

Cell culture and animal models currently used in the development of ASOs will be examined from the perspective of their suitability to assess ASO delivery and the toxicity of delivery systems.

After an initial meeting to share experiences, guidelines and SOPs will be drafted by members of this Working Group to include current models and recent developments, such as 3D cultures, organoids and tissue engineering techniques. It may be possible to reach out to other COST Actions interested in overlapping techniques, such as the CellFit COST Action CA16119. Outcome measures and delivery assessment workshops will be organised and validated SOPs will be uploaded in Action webpage and any interested network or scientific society’s webpage to be shared amongst the research community. read more

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