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WG2 Model systems
Cell culture and animal models currently used in the development of ASOs will be examined from the perspective of their suitability to assess ASO delivery and the toxicity of delivery systems. After an initial meeting to share experiences, guidelines and SOPs will be drafted by members of this Working Group to include current models and recent developments, such as 3D cultures, organoids and tissue engineering techniques. It may be possible to reach out to other COST Actions interested in overlapping methods, such as the CellFit COST Action CA16119. We will organise outcome measures and delivery assessment workshops and validated SOPs will be uploaded in Action webpage. To share the knowledge amongst the research community, we will encourage interested network or scientific society’s to place the deliverables mentioned above on their webpages.