WG3 Safety and toxicology
This WG deals with an issue often overlooked until late stages of development. This late analysis often derails the advance of delivery systems that should have been halted beforehand. With the organisation of a meeting and several workshops, members of this Working Group will seek consensus on the best in vitro and in vivo models to test early for toxicity (in collaboration with WG2), which tissues should be analysed and the best methods to check early for a possible immune response. This Working Group will deliver a series of SOPs and guidelines about how to study the toxicity of different delivery options, and SOPs will be uploaded in Action webpage and any interested network or scientific society’s webpage to be shared amongst the research community.