Purpose of the STSM:  In a recent work from the applicant’s lab, the team has shown the potential of glycosylated dynamic covalent polymers (DCPs) for the delivery of siRNA onto live cells (Ulrich, S. et al., Angew. Chem. Int. Ed. 2021, 60, 5783). Interestingly, they showed that those vectors are self-assembled in a siRNA-templated manner. After those promising results, they developed a new generation of DCPs, which have shown an improvement for siRNA complexation. Moreover, this new generation has been decorated with various functionalities known to promote the internalization and enhance the endosomal

In that context, and already having a promising background for gene delivery, Mr. José Garcia Coll wished to implement their
self-assembled approach to longer mRNA. Expanding its scope with the use of mRNA as therapeutic cargo will surely open a new promising direction in their research.

Grantee name: José Garcia Coll

STSM start and end date: 18/09/2022 to 29/09/2022

Title: Dynamic Covalent Polymers for mRNA complexation
Host lab: Prof. Javier Montenegro García, Center for Research in Biological Chemistry and Molecular Materials (CIQUS) (Santiago de Compostela, Spain)